Stone staircase in Relais Il Santissimo hotel with arched hallway and framed artworks.

A Boutique Hotel & Relais
in the heart of Puglia, Italy.

In the most authentic side of Puglia
beauty finds its home.

In its ancient historic residence, Il Santissimo welcomes couples and guests into a luxury relais where timeless elegance, quiet atmospheres and authentic hospitality come together.

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Shared emotions, shared memories

Whether for a romantic getaway, a destination wedding or a multi-day celebration, Il Santissimo transforms every moment into a shared experience to remember.

Tree-lined avenue leading to the entrance of the Relais Il Santissimo hotel between hedges and olive trees.

Lounge room of Relais Il Santissimo with stone vaults.

Outdoor garden at Relais Il Santissimo hotel with trees, hedges and stone little walls.

Breakfast with croissant and typical pastries.

Savory breakfast with focaccia, bruschette and mixed cold cuts platters.

Relais Il Santissimo hotel with stone vaults, plants and chandelier.

Stone hallway with chandelier and ancient furnishing.

The Palazzo’s enchantment

Our Palazzo preserves its timeless charm through elegant historic details. Surrounded by wide outdoor spaces and peaceful views, every room invites you to slow down and experience a stay shaped by beauty, silence and intimacy.

Hotel’s stone corridor with railings, wall art and historic details.

Hotel corridor with dark doors, paintings on the walls and a stone floor.

Bar area of Il Santissimo hotel relais features an illuminated counter, stone vaults and historic details.

Detail of the hotel’s external stone wall with window and ancient drainage hole.

Lounge area of the hotel with stone vaults, sofas and ancient chandeliers.

Hotel's internal staircase with stone vault, chandelier and historical details.

Ten rooms, four ways to experience Il Santissimo

Designed to welcome couples, destination wedding guests and intimate stays in Puglia, our ten rooms and suites combine comfort, privacy and authentic hospitality within the timeless atmosphere of the relais.

Choose your accommodation!

Suites dei Nobili

The most spacious and refined accommodations, each with its own distinctive character.
Suite del Massaro unfolds across two levels, with an exclusive wellness area and a private panoramic terrace, while Suite Padronale preserves the charm of the 19th century through generous spaces where comfort and elegance meet.

View from above of the Suite del Massaro with bed, stone walls, and period furnishings.

Suite del Massaro bathroom with sink, shower and stone walls.

Entrance to the suite with stone walls and ancient furnishings.

The bedroom area of the suite features stone vaults and ancient furnishings.

Suite del Massaro, a suite at hotel Relais Il Santissimo with stone vaults and ancient furnishings.

Suite Padronale of the Relais Il Santissimo hotel with an elegant lounge and historic vaults.

Suite Padronale bedroom area with double bed, blue wall, and open-plan living room.

Suite Padronale living room with sofa, blue walls and elegant furnishings.

Lounge area with armchair, coffee table and elegant curtains.

Suites Belvedere Terrace

Set within the former granary and reached by a striking drawbridge, these three suites feature large private terraces overlooking the Puglian countryside.

Suite Belvedere Terrace, with double bed and bedside lights.

Armonia Deluxe

Natural materials, soft atmospheres and the quiet beauty of the Masseria define these three intimate rooms. Each one has its own detail to discover: an original fireplace, garden views or a panoramic window framing the entrance of the estate.

Bathroom with freestanding tub, chandelier and bright window.

Aurora Comfort

Warm tones of wood and stone welcome guests into serene, sunlit rooms with private balconies overlooking the countryside. Ideal for those seeking simplicity, comfort and an authentic stay in Puglia.

Bathroom with glass shower, dark blue walls and light details.

Aurora Comfort room with double bed, taupe walls and bedside lights.

Discover iconic and authentic Apulian landscapes

Set between Bari and the Valle d’Itria, Il Santissimo is ideally located for discovering some of Puglia’s most iconic landmarks.

Explore the surroundings

From the Trulli of Alberobello to the white streets of Locorotondo, from Matera’s ancient Sassi to the landscapes of the Murgia countryside, every journey reveals authentic traditions, local culture and the timeless beauty of Southern Italy.

Perfectly positioned for destination weddings and multi-day celebrations, the relais allows guests to combine meaningful moments with the discovery of Puglia’s most authentic soul.

Trulli of Alberobello, historic village in the Itria Valley near Relais Il Santissimo.

Alcova dei Sensi

Alcova dei Sensi is the wellness sanctuary of Il Santissimo — an intimate spa where relaxation unfolds through regenerating massages and thermal baths experiences.

Our hotel with spa near Bari is ideal before or after a celebration, making wellness part of the overall experience of staying at the relais.

Discover tailored wellness experiences and thematic packages, and enjoy a luxury getaway designed around rest, beauty and renewal.

Wellness treatment table in the hotel spa.

Spa area of the Relais Il Santissimo hotel with sauna, hot tub and stone walls.

Stone relaxation room in the spa, with loungers and historic vaults.

Reception at the Alcova dei Sensi spa at Relais Il Santissimo, with stone walls and natural panels.

Bosco del Benessere

Surrounded by holm oaks and maritime pines, the Bosco del Benessere invites guests into a wellness path immersed in nature - a perfect moment of reflection and regeneration designed to nurture both body and mind.